Annals of internal medicine
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Randomized Controlled Trial
Unloading Shoes for Self-management of Knee Osteoarthritis: A Randomized Trial.
Appropriate footwear is recommended for self-management of knee osteoarthritis. Shoes that reduce harmful knee loads are available, but symptomatic effects are uncertain. ⋯ Australian National Health and Medical Research Council.
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Randomized Controlled Trial
Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized Trial.
The metabolic defects of nonalcoholic steatohepatitis (NASH) and prediabetes or type 2 diabetes mellitus (T2DM) seem to be specifically targeted by pioglitazone. However, information about its long-term use in this population is limited. ⋯ Burroughs Wellcome Fund and American Diabetes Association.
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Randomized Controlled Trial
Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial.
Few remedies effectively treat long-term pain and disability from knee osteoarthritis. Studies suggest that Tai Chi alleviates symptoms, but no trials have directly compared Tai Chi with standard therapies for osteoarthritis. ⋯ National Center for Complementary and Integrative Health of the National Institutes of Health.
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Randomized Controlled Trial
Gradual Versus Abrupt Smoking Cessation: A Randomized, Controlled Noninferiority Trial.
Most smoking cessation guidelines advise quitting abruptly. However, many quit attempts involve gradual cessation. If gradual cessation is as successful, smokers can be advised to quit either way. ⋯ British Heart Foundation.
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Randomized Controlled Trial Multicenter Study
Sex-Specific Differences at Presentation and Outcomes Among Patients Undergoing Transcatheter Aortic Valve Replacement: A Cohort Study.
Female sex is associated with poorer outcomes after surgical aortic valve replacement (SAVR). Data on sex-specific differences after transcatheter aortic valve replacement (TAVR) are conflicting. ⋯ Edwards Lifesciences.