Annals of internal medicine
-
Randomized Controlled Trial Comparative Study Pragmatic Clinical Trial
One-year outcome of subacromial corticosteroid injection compared with manual physical therapy for the management of the unilateral shoulder impingement syndrome: a pragmatic randomized trial.
Corticosteroid injections (CSIs) and physical therapy are used to treat patients with the shoulder impingement syndrome (SIS) but have never been directly compared. ⋯ Cardon Rehabilitation Products through the American Academy of Orthopaedic Manual Physical Therapists.
-
Randomized Controlled Trial
Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIV-1-uninfected men and women: a subgroup analysis of a randomized trial.
Daily oral preexposure prophylaxis (PrEP) using the antiretroviral tenofovir disoproxil fumarate (TDF) alone or in combination with emtricitabine (FTC-TDF) reduces the risk for HIV-1 acquisition. Tenofovir has in vitro activity against herpes simplex virus type 2 (HSV-2). ⋯ Bill & Melinda Gates Foundation.
-
Randomized Controlled Trial
N-of-1 (single-patient) trials for statin-related myalgia.
Statin-related myalgia is difficult to distinguish from other conditions causing myalgia and may often lead to statin discontinuation. ⋯ Western University, London, Ontario, Canada.
-
Randomized Controlled Trial Multicenter Study
Treatment of primary Sjögren syndrome with rituximab: a randomized trial.
Primary Sjögren syndrome (pSS) is an autoimmune disorder characterized by ocular and oral dryness or systemic manifestations. ⋯ Rituximab did not alleviate symptoms or disease activity in patients with pSS at week 24, although it alleviated some symptoms at earlier time points.
-
Randomized Controlled Trial Multicenter Study
Prevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial.
Interventions promoting weight loss can reduce the incidence of type 2 diabetes mellitus. Whether dietary changes without calorie restriction also protect from diabetes has not been evaluated. ⋯ Instituto de Salud Carlos III.