Annals of internal medicine
-
Randomized Controlled Trial
Methylprednisolone injections for the carpal tunnel syndrome: a randomized, placebo-controlled trial.
Steroid injections are used in idiopathic carpal tunnel syndrome (CTS), but evidence of efficacy beyond 1 month is lacking. ⋯ Region of Scania Research and Development Foundation and Hässleholm Hospital Organization.
-
Randomized Controlled Trial Multicenter Study
Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial.
Many patients with rheumatoid arthritis (RA) do not achieve adequate and safe responses with disease-modifying antirheumatic drugs (DMARDs). Tofacitinib is a novel, oral, Janus kinase inhibitor that treats RA. ⋯ Pfizer.
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial.
Short-duration studies show that salsalate improves glycemia in type 2 diabetes mellitus (T2DM). ⋯ Salsalate improves glycemia in patients with T2DM and decreases inflammatory mediators. Continued evaluation of mixed cardiorenal signals is warranted.
-
Randomized Controlled Trial Comparative Study
Clinical outcomes with rivaroxaban in patients transitioned from vitamin K antagonist therapy: a subgroup analysis of a randomized trial.
In ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation), a large randomized, clinical trial, rivaroxaban was noninferior to warfarin in preventing stroke or systemic embolism in patients with atrial fibrillation. ⋯ Johnson & Johnson and Bayer HealthCare.
-
Randomized Controlled Trial Multicenter Study Comparative Study
Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial.