Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial.
Idiopathic pulmonary fibrosis (IPF) is characterized by formation and proliferation of fibroblast foci. Endothelin-1 induces lung fibroblast proliferation and contractile activity via the endothelin A (ETA) receptor. ⋯ Gilead Sciences.
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Randomized Controlled Trial Multicenter Study
Action to stop smoking in suspected tuberculosis (ASSIST) in Pakistan: a cluster randomized, controlled trial.
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Randomized Controlled Trial Multicenter Study
An automated intervention with stepped increases in support to increase uptake of colorectal cancer screening: a randomized trial.
Screening decreases colorectal cancer (CRC) incidence and mortality, yet almost half of age-eligible patients are not screened at recommended intervals. ⋯ Compared with usual care, a centralized, EHR-linked, mailed CRC screening program led to twice as many persons being current for screening over 2 years. Assisted and navigated interventions led to smaller but significant stepped increases compared with the automated intervention only. The rapid growth of EHRs provides opportunities for spreading this model broadly.
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Randomized Controlled Trial Multicenter Study
Acupuncture in patients with seasonal allergic rhinitis: a randomized trial.
Chinese translation ⋯ Acupuncture led to statistically significant improvements in disease-specific quality of life and antihistamine use measures after 8 weeks of treatment compared with sham acupuncture and with RM alone, but the improvements may not be clinically significant.
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Randomized Controlled Trial
Improved immunogenicity with high-dose seasonal influenza vaccine in HIV-infected persons: a single-center, parallel, randomized trial.
HIV-infected persons have less robust antibody responses to influenza vaccines. ⋯ National Institute of Allergy and Infectious Diseases and Center for AIDS Research of the University of Pennsylvania.