Annals of internal medicine
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Review Randomized Controlled Trial Multicenter Study
Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial.
Perineural inhibitors of tumor necrosis factor have recently generated intense interest as an alternative to epidural steroid injections for lumbosacral radiculopathy. ⋯ The John P. Murtha Neuroscience and Pain Institute, International Spinal Intervention Society, and Center for Rehabilitation Sciences Research.
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Randomized Controlled Trial Multicenter Study
Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial.
Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2, may improve glycemic control with a lower dose of insulin and attenuate the associated weight gain in patients with inadequate control despite high doses of insulin. ⋯ AstraZeneca and Bristol-Myers Squibb.
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Randomized Controlled Trial Comparative Study
Peer mentoring and financial incentives to improve glucose control in African American veterans: a randomized trial.
Compared with white persons, African Americans have a greater incidence of diabetes, decreased control, and higher rates of microvascular complications. A peer mentorship model could be a scalable approach to improving control in this population and reducing disparities in diabetic outcomes. ⋯ National Institute on Aging Roybal Center.
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Randomized Controlled Trial
High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial.
Low serum 25-hydroxyvitamin D (25-[OH]D) levels have been associated with lower FEV(1), impaired immunologic control, and increased airway inflammation. Because many patients with chronic obstructive pulmonary disease (COPD) have vitamin D deficiency, effects of vitamin D supplementation may extend beyond preventing osteoporosis. ⋯ Applied Biomedical Research Program, Agency for Innovation by Science and Technology (IWT-TBM).
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Randomized Controlled Trial Multicenter Study
Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain: a randomized trial.
Mechanical neck pain is a common condition that affects an estimated 70% of persons at some point in their lives. Little research exists to guide the choice of therapy for acute and subacute neck pain. ⋯ National Center for Complementary and Alternative Medicine, National Institutes of Health.