Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
Cumulative incidence of false-positive test results in lung cancer screening: a randomized trial.
Direct-to-consumer promotion of lung cancer screening has increased, especially low-dose computed tomography (CT). However, screening exposes healthy persons to potential harms, and cumulative false-positive rates for low-dose CT have never been formally reported. ⋯ National Cancer Institute.
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Randomized Controlled Trial Multicenter Study
Coronary heart disease in postmenopausal recipients of estrogen plus progestin therapy: does the increased risk ever disappear? A randomized trial.
Estrogen plus progestin therapy increases the risk for coronary heart disease (CHD) in postmenopausal women. However, this increased risk might be limited to the first years of use and to women who start therapy late in menopause. ⋯ National Heart, Lung, and Blood Institute.
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Randomized Controlled Trial Comparative Study
Effectiveness of extended-duration transdermal nicotine therapy: a randomized trial.
Tobacco dependence is a chronic, relapsing condition that may require extended treatment. ⋯ National Institutes of Health.
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Randomized Controlled Trial
Intravenous immunoglobulin treatment of the complex regional pain syndrome: a randomized trial.
Treatment of long-standing complex regional pain syndrome (CRPS) is empirical and often of limited efficacy. Preliminary data suggest that the immune system is involved in sustaining this condition and that treatment with low-dose intravenous immunoglobulin (IVIG) may substantially reduce pain in some patients. ⋯ Association of Anaesthetists of Great Britain and Ireland, University College London Hospitals Charity, and CSL-Behring.
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Randomized Controlled Trial
Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial.
It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin. ⋯ Among low-dose aspirin recipients who had peptic ulcer bleeding, continuous aspirin therapy may increase the risk for recurrent bleeding but potentially reduces mortality rates. Larger trials are needed to confirm these findings.