Annals of internal medicine
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Randomized Controlled Trial Comparative Study
Comparing yoga, exercise, and a self-care book for chronic low back pain: a randomized, controlled trial.
Chronic low back pain is a common problem that has only modestly effective treatment options. ⋯ Yoga was more effective than a self-care book for improving function and reducing chronic low back pain, and the benefits persisted for at least several months.
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Randomized Controlled Trial Multicenter Study
Plasma exchange when myeloma presents as acute renal failure: a randomized, controlled trial.
Two small, randomized trials provide conflicting evidence about the benefits of plasma exchange for patients with acute renal failure at the onset of multiple myeloma. ⋯ In patients with acute renal failure at the onset of multiple myeloma, there is no conclusive evidence that 5 to 7 plasma exchanges substantially reduce a composite outcome of death, dialysis dependence, or glomerular filtration rate less than 0.29 mL.s(-2).m(-2) (<30 mL/min per 1.73 m2) at 6 months.
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Randomized Controlled Trial Multicenter Study
Treatment of lateral epicondylitis with botulinum toxin: a randomized, double-blind, placebo-controlled trial.
Lateral epicondylitis is a common condition for which botulinum toxin has been reported to have a therapeutic role in uncontrolled studies. ⋯ Botulinum toxin injection may improve pain over a 3-month period in some patients with lateral epicondylitis, but injections may be associated with digit paresis and weakness of finger extension.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial.
Physicians may use either insulin or exenatide injections for patients with type 2 diabetes mellitus who have poor glycemic control despite taking oral blood glucose-lowering drugs. ⋯ Exenatide and insulin glargine achieved similar improvements in overall glycemic control in patients with type 2 diabetes that was suboptimally controlled with oral combination therapy. Exenatide was associated with weight reduction and had a higher incidence of gastrointestinal adverse effects than insulin glargine.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections: a randomized, controlled trial.
Central venous catheter-related infections are a significant medical problem. Improved preventive measures are needed. ⋯ The second-generation chlorhexidine-silver sulfadiazine catheter is well tolerated. Antiseptic coating appears to reduce microbial colonization of the catheter compared with an uncoated catheter.