Annals of surgery
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Comparative Study
Ex vivo lung evaluation of prearrest heparinization in donation after cardiac death.
To evaluate the effects of prearrest heparin administration on lung quality in a model of donation after cardiac death (DCD), and to assess the potential application of ex vivo lung perfusion (EVLP) in the identification of better grafts from the DCD donor pool. ⋯ Prearrest heparin administration improved organ function by preserving endothelial homeostasis. EVLP proved to be a useful platform for assessing DCD lungs, providing reliable means of discriminating injured grafts.
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Comparative Study
Single-port donor nephrectomy provides improved patient satisfaction and equivalent outcomes.
Minimally invasive techniques have expanded the donor pool for living kidney donation. We changed our approach to single-port donor nephrectomy in 2009 and have compared outcomes with traditional multiple-port laparoscopic donor nephrectomy. ⋯ Single-port donor nephrectomy can be integrated as a standardized approach for renal donation without additional donor risk, and with benefits of improved patient satisfaction with cosmetic and overall outcomes. Although the primary benefit is cosmetic, (a single incision predominantly contained within the umbilicus) outcomes justify application for kidney donors in experienced centers and may motivate additional living kidney donation.
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Comparative Study
Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold.
Generation of human livers in pigs might improve the serious shortage of grafts for human liver transplantation, and enable liver transplantation without the need for deceased or living donors. We developed a chimeric liver (CL) by repopulation of rat hepatocytes in a mouse and successfully transplanted it into a rat recipient with vessel reconstruction. This study was designed to investigate the feasibility of CL for supporting the recipient after auxiliary liver grafting. ⋯ This is the first report showing that engineered CLs have potential as alternative grafts to replace the use of grafts from human donors.
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Multicenter Study Comparative Study
Predictors of nursing home admission, severe functional impairment, or death one year after surgery for non-small cell lung cancer.
To assess factors associated with nursing home admission, severe functional impairment, or death 1 year after surgery for stage I-IIIa non-small cell lung cancer. ⋯ Patients' risk of long-term disability should be incorporated in preoperative counseling.