Annals of surgery
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Comparative Study
Striving for work-life balance: effect of marriage and children on the experience of 4402 US general surgery residents.
To determine how marital status and having children impact US general surgical residents' attitudes toward training and personal life. ⋯ Residents who were married or parents reported greater satisfaction and work-life conflict. The complex effects of family on surgical residents should inform programs to target support mechanisms for their trainees.
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Comparative Study
Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold.
Generation of human livers in pigs might improve the serious shortage of grafts for human liver transplantation, and enable liver transplantation without the need for deceased or living donors. We developed a chimeric liver (CL) by repopulation of rat hepatocytes in a mouse and successfully transplanted it into a rat recipient with vessel reconstruction. This study was designed to investigate the feasibility of CL for supporting the recipient after auxiliary liver grafting. ⋯ This is the first report showing that engineered CLs have potential as alternative grafts to replace the use of grafts from human donors.