Annals of surgery
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To test whether a clinical algorithm using routine cytological molecular testing (MT) promotes initial total thyroidectomy (TT) for clinically significant thyroid cancer (sTC) and/or correctly limits surgery to lobectomy when appropriate. ⋯ Fine-needle aspiration biopsy MT for BRAF, RAS, PAX8-PPARγ, and RET-PTC expedites optimal initial surgery for differentiated thyroid cancer, facilitating succinct definitive management for patients with thyroid nodules.
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Randomized Controlled Trial
A randomized, controlled, crossover study of sacral nerve stimulation for irritable bowel syndrome.
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Comparative Study
Comparison of cancer-associated genetic abnormalities in columnar-lined esophagus tissues with and without goblet cells.
To determine and compare the frequency of cancer-associated genetic abnormalities in esophageal metaplasia biopsies with and without goblet cells. ⋯ This study reports the largest and most comprehensive comparison of DNA aberrations in IM and NGM genomes. Our results show that IM has a much higher frequency of cancer-associated mutations than NGM.
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To propose an anatomical classification of congenital portosystemic shunts (CPSs) correlating with conservative surgery. ⋯ Our classification correlates the anatomy of CPSs and the surgical strategy: outcomes are good provided end-to-side-like portal-caval shunts patients have a 2-stage closure, side-to-side portal-caval shunts patients have a 1-stage caval partition, and the others have a 1-stage ligation.
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To determine the impact of the increasing aging population on trauma mortality relative to mortality from cancer and heart disease in the United States. ⋯ Trauma is now the leading cause of death for individuals 46 years and younger. The largest increase in the number of trauma deaths and the highest crude number of trauma deaths occurred in baby boomers. Policy makers allocating resources should be made aware of the larger impact of trauma on our aging and burgeoning US population.