Annals of surgery
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Clinical Trial
Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study.
To characterize the relationship between tranexamic acid (TXA) use and patient outcomes in a severely injured civilian cohort, and to determine any differential effect between patients who presented with and without shock. ⋯ TXA as part of a major hemorrhage protocol within a mature civilian trauma system provides outcome benefits specifically for severely injured shocked patients.
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Observational Study
Risk of perioperative respiratory complications and postoperative morbidity in a cohort of adults exposed to passive smoking.
To evaluate the risks of perioperative respiratory complications and postoperative morbidity associated with active and passive cigarette smoking. ⋯ One in 5 adults was exposed to environmental tobacco smoke before surgery. Passive cigarette smoking showed very little, if any, increased risk of perioperative respiratory complications. Both active exposure and passive exposure to cigarette smoke increased the risk of postoperative morbidity.
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To determine the absolute and relative risk of acute appendicitis during the antepartum and postpartum periods compared with the time outside pregnancy among women of childbearing age. ⋯ Pregnant women are less likely to be diagnosed with acute appendicitis than nonpregnant women, with the lowest risk reported during the third trimester.
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The overall aim was to develop and validate a risk prediction score for laparoscopic colorectal surgery training cases. ⋯ A risk predication score to facilitate case selection in laparoscopic colorectal surgery training was developed and validated.
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To determine the association of sarcopenia with postoperative morbidity and mortality after colorectal surgery. ⋯ Functional compromise in colorectal cancer surgery is associated with adverse postoperative outcome. Assessment of functional compromise by means of a nutritional questionnaire (Short Nutritional Assessment Questionnaire), a frailty questionnaire (Groningen Frailty Indicator), and sarcopenia measurement (L3 muscle index) can accurately predict postoperative sepsis.