Annals of surgery
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To update and examine national temporal trends in contralateral prophylactic mastectomy (CPM) and determine whether survival differed for invasive breast cancer patients based on hormone receptor (HR) status and age. ⋯ The use of CPM more than tripled during the study period despite evidence suggesting no survival benefit over breast conservation. Further examination on how to optimally counsel women about surgical options is warranted.
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Comparative Study
Cyclooxygenase-2 Is Essential for Colorectal Anastomotic Healing.
To study the effects of COX-2 on colonic surgical wound healing. ⋯ COX-2-induced PGE2 production is essential for intestinal wound healing after colonic surgery, possibly via its effects on angiogenesis. These data emphasize that COX-2 inhibitors should be avoided after colonic surgery, and administration of PGE2 might be favorable for a selection of patients.
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The purpose of this study was to assess whether perfusion-decellularization technology could be applied to facial grafts. ⋯ Acellular scaffolds were produced from the porcine ear, and may be a valuable platform to treat facial deformities using regenerative medicine approaches.