Annals of surgery
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The objective of this study was to evaluate if a preoperative wellness bundle significantly decreases the risk of hospital acquired infections (HAI). ⋯ A novel, preoperative, patient-centered wellness program dramatically reduced HAI in surgical patients at an urban academic medical center.
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Most risk assessment tools assume that the impact of risk factors is linear and cumulative. Using novel machine-learning techniques, we sought to design an interactive, nonlinear risk calculator for Emergency Surgery (ES). ⋯ POTTER is a highly accurate and user-friendly ES risk calculator with the potential to continuously improve accuracy with ongoing machine-learning. POTTER might prove useful as a tool for bedside preoperative counseling of ES patients and families.
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Acute liver failure (ALF) affects 2000 Americans each year with no treatment options other than liver transplantation. We showed previously that mobilization of endogenous stem cells is protective against ALF in rodents. The objective of this study was to assess whether stem cell mobilizing drugs are lifesaving in a large animal preclinical model of ALF, to assess readiness for a clinical trial. ⋯ Stem cell mobilizing drugs were lifesaving in a preclinical large animal model of ALF. Since no therapeutic options other than liver transplantation are currently available for critically ill patients with ALF, a multicenter clinical trial is warranted.