Annals of surgery
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To compare performances for predicting surgical difficulty and postoperative complications. ⋯ The complexity classification outperformed the major/minor classification for predicting the surgical difficulty of liver resection.
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: Limited recent data exist regarding intended retirement plans for general surgeons (GS). We sought to understand when and why surgeons decide to stop operating as primary surgeon and stop all clinical work. A paper-based survey of practicing GS in the province of Ontario, Canada, was conducted. ⋯ Overall, GS plan to stop operating at age 65, and to cease all clinical activities at age 70. Younger, nonacademic surgeons plan to stop operating earlier. Career satisfaction, sense of identity, and financial need are the principal reported motivations to continue operating.
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To identify molecular prognostic factors and potentially actionable mutations in ampulla of Vater cancer (AVC). ⋯ KRAS and TP53 mutations are negative predictors of survival in AVCs, regardless of histotype. Potentially actionable mutations in ERBB, WNT, and PI3K signaling pathway genes are present in 37.5% of all cases. These might be amenable to target therapy using available drugs like Everolimus in PI3K-mutated cases or compounds under active screening against ERBB and WNT signaling.