Annals of surgery
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The aim of this study was to determine the predictive value of machine perfusate analysis on graft outcome. ⋯ Assessment of flavin, a marker of mitochondrial complex I injury, in the perfusate provides a fast prediction of liver graft function and loss during ex situ MP before implantation. This finding may have high clinical relevance, as liver grafts from extended DBD or DCD donors carry considerable risks for recipients. On-line estimation of outcome before implantation would therefore substantially increase safe utilization of liver grafts.
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To explore the determinants of postoperative outcomes of adrenal surgery in order to build a proposition for healthcare improvement. ⋯ High-risk patients should be referred to high-volume centers for adrenal surgery.