Annals of surgery
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The aim of this study was to determine whether the genetic background of the disease should be incorporated into treatment decision making. ⋯ Mutations in the SDHB gene are associated with worse disease-free survival after resection in patients with carotid body paragangliomas despite earlier intervention. This suggests that a more aggressive surgical approach is warranted in patients with SDHB mutations.
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The role for neoadjuvant systemic therapy in resectable pancreas adenocarcinoma remains undefined. ⋯ This study met its endpoint and provided a signal suggesting that exploration of neoadjuvant systemic therapy is worthy of further investigation in resectable pancreas adenocarcinoma. Improved patient selection and more active systemic regimens are key. Clinical trials identification: NCT00536874.
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Comparative Study
Comparison of cancer-associated genetic abnormalities in columnar-lined esophagus tissues with and without goblet cells.
To determine and compare the frequency of cancer-associated genetic abnormalities in esophageal metaplasia biopsies with and without goblet cells. ⋯ This study reports the largest and most comprehensive comparison of DNA aberrations in IM and NGM genomes. Our results show that IM has a much higher frequency of cancer-associated mutations than NGM.
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To determine the impact of the increasing aging population on trauma mortality relative to mortality from cancer and heart disease in the United States. ⋯ Trauma is now the leading cause of death for individuals 46 years and younger. The largest increase in the number of trauma deaths and the highest crude number of trauma deaths occurred in baby boomers. Policy makers allocating resources should be made aware of the larger impact of trauma on our aging and burgeoning US population.