Annals of surgery
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Randomized Controlled Trial Comparative Study Clinical Trial
Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection.
To test the hypothesis that routine intraperitoneal drainage is not required after pancreatic resection. ⋯ This randomized prospective clinical trial failed to show a reduction in the number of deaths or complications with the addition of surgical intraperitoneal closed suction drainage after pancreatic resection. The data suggest that the presence of drains failed to reduce either the need for interventional radiologic drainage or surgical exploration for intraabdominal sepsis. Based on these results, closed suction drainage should not be considered mandatory or standard after pancreatic resection.
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Randomized Controlled Trial Comparative Study Clinical Trial
A prospective comparison of simultaneous kidney-pancreas transplantation with systemic-enteric versus portal-enteric drainage.
To compare pancreas transplantation with systemic-enteric (SE) versus portal-enteric (PE) drainage in a prospective fashion. ⋯ These results suggest that simultaneous kidney and pancreas transplantation with SE or PE drainage can be performed with comparable short-term outcomes.
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Randomized Controlled Trial Clinical Trial
Attenuation of posttraumatic muscle catabolism and osteopenia by long-term growth hormone therapy.
To determine whether the beneficial effects of growth hormone persist throughout the prolonged hypermetabolic and hypercatabolic response to severe burn. ⋯ Low-dose recombinant human growth hormone successfully abates muscle catabolism and osteopenia induced by severe burn.
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Randomized Controlled Trial Clinical Trial
Double-blind placebo-controlled trial of fluconazole to prevent candidal infections in critically ill surgical patients.
To evaluate the prophylactic use of enteral fluconazole to prevent invasive candidal infections in critically ill surgical patients. ⋯ Enteral fluconazole safely and effectively decreased the incidence of fungal infections in high-risk, critically ill surgical patients.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Randomized trial of choledochocholedochostomy with or without a T tube in orthotopic liver transplantation.
To compare the incidence of biliary complications after liver transplantation in patients undergoing choledochocholedochostomy reconstruction with or without T tube in a multicenter, prospective, randomized trial. ⋯ This study is the first large prospective, randomized trial of biliary complications with or without a T tube. The authors found an increase in the biliary complication rate in the T-tube group, which was linked to minor complications. The T tube did not provide a safer access to the biliary tree compared with the others types of biliary explorations. The authors recommend the performance of choledochocholedochostomy without a T tube in liver transplantation.