Annals of surgery
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Randomized Controlled Trial Multicenter Study
Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study.
To determine whether regional hyperthermia (RHT) in addition to chemotherapy improves local tumor control after macroscopically complete resection of abdominal or retroperitoneal high-risk sarcomas. ⋯ In patients with macroscopically complete tumor resection, RHT in addition to chemotherapy resulted in significantly improved local tumor control and DFS without increasing surgical complications. Within a multimodal therapeutic concept for abdominal and retroperitoneal high-risk sarcomas, RHT is a treatment option beside radical surgery and should be further evaluated in future trials.
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Randomized Controlled Trial Multicenter Study
Prolonged time to surgery after neoadjuvant chemoradiotherapy increases histopathological response without affecting survival in patients with esophageal or junctional cancer.
To determine the relation between time to surgery (TTS) after neoadjuvant chemoradiotherapy (nCRT) and pathologically complete response (pCR), surgical outcome, and survival in patients with esophageal cancer. ⋯ Prolonged TTS after nCRT increases the probability of pCR and is associated with a slightly increased probability of postoperative complications, without affecting disease-free and overall survivals. We conclude that TTS can be safely prolonged from the usual 4 to 6 weeks up to at least 12 weeks, which facilitates a more conservative wait-and-see strategy after neoadjuvant chemoradiotherapy to be tested.
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Multicenter Study Clinical Trial Observational Study
Relevance of postoperative peak transaminase after elective hepatectomy.
Determine whether inflow occlusion is correlated with peak-postoperative serum-transaminases (PSTs) and whether PST is predictive of outcome after liver resections. ⋯ PST is not correlated with ischemia time and should not be used as a surrogate of postoperative outcome.
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Multicenter Study
Preoperative Pancreatic Resection (PREPARE) score: a prospective multicenter-based morbidity risk score.
Development of a simple preoperative risk score to predict morbidity related to pancreatic surgery. ⋯ We present an easily applied scoring system with convincing accuracy for identifying low-risk and high-risk patients. In contrast to other systems, the score is exclusively based on objective preoperatively assessable characteristics and can be rapidly and easily calculated.
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Multicenter Study
"Surgeons' intuition" versus "prognostic models": predicting the risk of liver resections.
Analyze surgeons' anticipation of the risk of hepatectomy. ⋯ Surgeons should be aware of the limited accuracy of their intuition.