Annals of surgery
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Randomized Controlled Trial Comparative Study Clinical Trial
A prospective randomized study on bilateral carotid endarterectomy: patching versus eversion.
To compare the clinical outcome and restenosis incidence of patients who underwent carotid endarterectomy with patch closure (CEAP) on one side and carotid eversion endarterectomy (CEE) on the other. ⋯ CEE is less likely to cause perioperative neurologic complications and restenoses than CEAP. The significantly higher rate of unilateral recurrence suggests that local factors play a more important role than systemic factors in the occurrence of restenosis.
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Randomized Controlled Trial Clinical Trial
Sequential cytokine therapy for pressure ulcers: clinical and mechanistic response.
To compare the healing response of sequential topically applied cytokines to that of each cytokine alone and to a placebo in pressure ulcers, and to evaluate the molecular and cellular responses. ⋯ Treatment with bFGF resulted in significantly greater healing than the other treatments in this trial. The clinical response appeared to be related to upregulation of the bFGF message and to increased levels of PDGF-AB, bFGF, and TGFbeta1 in the wounds and changes in ultrastructure. The resultant improvements could be correlated with cost savings.
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Randomized Controlled Trial Clinical Trial
Protein-sparing effect in skeletal muscle of growth hormone treatment in critically ill patients.
To investigate the effect of growth hormone (GH) treatment on skeletal muscle protein catabolism in patients with multiple organ failure in the intensive care unit (ICU). ⋯ Treatment with GH for 5 days in patients with multiple organ failure stimulated muscle protein synthesis, increased muscle free glutamine, and increased intracellular muscle water.
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Randomized Controlled Trial Comparative Study Clinical Trial
Ultrasonically activated shears in thyroidectomies: a randomized trial.
To test whether the advantages of the ultrasonically activated shears (UAS) observed in thyroidectomies in a previous matched-pair study could be repeated in a randomized trial. ⋯ The UAS is a usable device in total thyroidectomies and lobectomies.
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Randomized Controlled Trial Clinical Trial
Stapled versus sutured closure of loop ileostomy: a randomized controlled trial.
To compare the outcome after conventional sutured loop ileostomy closure with stapled ileostomy closure. ⋯ Bowel obstruction occurred less frequently after stapled closure, but the mean hospital stay and readmission and reoperation rate did not significantly differ between the two groups.