Annals of surgery
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Randomized Controlled Trial Multicenter Study Observational Study
Surgical Complications in a Multicenter Randomized Trial Comparing Preoperative Chemoradiotherapy and Immediate Surgery in Patients With Resectable and Borderline Resectable Pancreatic Cancer (PREOPANC Trial).
To investigate the effect of preoperative chemoradiotherapy on surgical complications in patients after pancreatic resection for (borderline-)resectable pancreatic cancer. ⋯ Preoperative chemoradiotherapy did not increase the incidence of surgical complications or mortality and reduced the rate of postoperative pancreatic fistula after resection in patients with (borderline-)resectable pancreatic cancer.
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Randomized Controlled Trial Multicenter Study
The Conventional Technique Versus the No-Touch Isolation Technique for Primary Tumor Resection in Patients With Colon Cancer (JCOG1006): A Multicenter, Open-Label, Randomized, Phase III Trial.
This phase III trial evaluated whether the no touch was superior to the conventional in patients with cT3/T4 colon cancer. ⋯ The present study failed to confirm the superiority of the no touch.
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Randomized Controlled Trial Multicenter Study
Antiseptic Skin Agents to Prevent Surgical Site Infection after Incisional Surgery: A Randomized, Three-Armed Combined Non-Inferiority and Superiority Clinical Trial (NEWSkin Prep Study).
To compare SSI rates between the skin preparation agents: PI-Aq, povidone-iodine with alcohol (PI-Alc), and chlorhexidine with alcohol (C-Alc). ⋯ PI-Alc is non-inferior to C-Alc and not superior to PI-Aq. This is at odds with current guidelines that suggest alcohol-based chlorhexidine solutions should routinely be used for surgical skin preparation.
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To investigate the impact of thoracic body composition on outcomes after lobectomy for lung cancer. ⋯ Body composition on preoperative chest computed tomography is an independent predictor of LOS and postoperative complications after lobectomy for lung cancer.
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Multicenter Study Observational Study
External Validity of the Multicenter Randomized PREOPANC Trial on Neoadjuvant Chemoradiotherapy in Pancreatic Cancer: Outcome of Eligible But Non-Randomized Patients.
To investigate the accrual proportion and patients' reasons for not participating in the PREOPANC trial on neoadjuvant chemoradiotherapy versus immediate surgery in resectable and borderline resectable pancreatic cancer, and to compare these patients' outcomes with those of patients who had been randomized in the trial. ⋯ The PREOPANC trial included a reasonable percentage of 33% of eligible patients. In terms of the outcomes survival, resection rate, and R0 resection rate, this appeared to be a representative group.