Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Jun 2021
Case ReportsTopiramate-induced Acute Transient Myopia and Angle Narrowing.
Sulphamate drugs, widely prescribed for various systemic conditions, are reported to have rare ocular adverse-effects, usually within weeks of initiation of treatment. Medical and drug history in such cases are of pivotal importance in reaching a proper diagnosis. This study reports three cases, which developed topiramate-induced ocular side effects. ⋯ Also, in the third case, there were no macular striae. Topiramate was immediately withheld and all cases were improved without any permanent ocular damage. Key Words: Sulphamate, Topiramate, Angle closure glaucoma, Myopia.
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J Coll Physicians Surg Pak · Jun 2021
Problem-based Learning and Team-based Learning as a Novel Package Approach.
To identify the insights of dentistry students towards a new 3/1 problem-based learning (PBL) and team-based learning (TBL) blended package approach. ⋯ Students valued the novel PBL-TBL package as an optimum learning approach. They predominantly voted in favour of TBL. Students further identified the sequence and format of the current approach conducive to learning, feedback and assessment. Key Words: Hybrid curriculum, Team-based learning, Problem-based learning, Blended learning, Innovative instructional strategy.
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J Coll Physicians Surg Pak · Jun 2021
Observational StudyRelationship between Vitamin D Deficiency, Albuminuria, Peripheral Artery Disease and 5-year Mortality in Chronic Kidney Disease.
To investigate the effects of vitamin D deficiency, albuminuria and peripheral artery disease (PAD) relationships, on 5-year mortality in patients with chronic kidney disease (CKD) . ⋯ A total of 110 CKD patients, mean age of 62.1±9.7 years, 36.4% women, were included in the study. It was found that 17.3% of the patients had vitamin D deficiency, 15.4% had vitamin D insufficiency, 32.7% had asymptomatic PAD, 33.9% had microalbuminuria and 39.4% had macroalbuminuria. It was observed that as vitamin D levels decreased, the frequency of albuminuria, and the prevalence of PAD, was on an increasing trend. A significant correlation was found between 5-year mortality, gender, body mass index (BMI), glomerular filtration rate (eGFR), urine albumin creatinine ratio (UACR), hemoglobin A1c (A1c), calcium (Ca), phosphate (P), vitamin D, ankle brachial index (ABI), and the neutrophil lymphocyte ratio (NLR) as a result of univariate cox-regressionanalysis. In the multivariate cox-regression model, it was observed that vitamin D, ABI and UACR levels continued being significant, independent of age, gender, BMI and eGFR levels. Conclusion: Vitamin D deficiency, PAD and albuminuria, which are separate predictors of mortality, were shown to be independent predictors of long-term mortality in CKD patients. Key Words: Chronic kidney disease, Mortality, Peripheral arterial disease, Vitamin D deficiency, Albuminuria, Ankle-brachial index.
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J Coll Physicians Surg Pak · Jun 2021
Case ReportsNovel Inflammatory Biomarkers in Patients with Mycosis Fungoides Treated with Bexarotene.
Mycosis fungoides (MF) is a skin lymphoma characterised by atypical T lymphocyte infiltration, which may present with patches and tumors in advanced stages. Treatment options in MF aim to reduce symptoms, since patients usually do not achieve complete cure. Bexarotene is used for treatment-resistant early stage MF and advanced stages of the disease. ⋯ We suggest that these inflammatory biomarkers can be used in the follow-up of patients with MF receiving bexarotene treatment. Moreover, these results indicate that decrease in these inflammatory biomarkers may signify improvement of the disease. Key Words: Bexarotene, İnflammatory biomarkers, Mycosis fungoides.
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J Coll Physicians Surg Pak · Jun 2021
Case ReportsHypersensitivity Pneumonitis in a Pediatric Patient.
Hypersensitivity pneumonitis (HP) is a rarely diagnosed interstitial lung disease with variable manifestations. It results from repeated inhalation of certain antigens, e.g. mold, avian antigen, etc. in susceptible patients. The diagnosis is made by exposure history, relevant clinical presentation, and specific radiologic features. ⋯ We report a 7.5-year girl with HP. She was admitted for cough and severe respiratory distress. Key Words: Hypersensitivity pneumonitis, Antigen, Allergy, Child.