The American journal of managed care
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To date, breakthrough chimeric antigen receptor (CAR) T-cell therapies, such as tisagenlecleucel, indicated for pediatric acute lymphoblastic leukemia (pALL) and diffuse large B-cell lymphoma (DLBCL), and axicabtagene ciloleucel, indicated for DLBCL, although clinically effective, have been limited by treatment delays. Our study measured the social value of CAR T-cell therapy (CAR T) for relapsed or refractory pALL and DLBCL in the United States and quantified social value lost due to treatment delays. ⋯ The social value of CAR T is significantly limited by treatment delays. Efficient payment mechanisms, adequate capital, and payment policy reform are urgently needed to increase patient access and maximize the value of CAR T.
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Observational Study
The adoption and spread of hospital care coordination activities under value-based programs.
To examine the relationship between participation in value-based programs and care coordination activities. ⋯ Value-based programs such as ACOs appear to encourage the adoption and spread of care coordination activities by hospitals.