Archives of disease in childhood
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Randomized Controlled Trial
Randomised controlled trial of combined paracetamol and ibuprofen for fever.
A randomised open label study of the combined use of paracetamol and ibuprofen to rapidly reduce fever is reported. The advantage of using both medications is less than half a degree centigrade in the first hour, and insufficient to warrant routine use.
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Randomized Controlled Trial Comparative Study
Isotonic is better than hypotonic saline for intravenous rehydration of children with gastroenteritis: a prospective randomised study.
To determine whether the risk of hyponatraemia in children with gastroenteritis receiving intravenous (IV) fluids is decreased by the use of 0.9% saline. ⋯ In gastroenteritis treated with intravenous fluids, normal saline is preferable to hypotonic saline because it protects against hyponatraemia without causing hypernatraemia.
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Randomized Controlled Trial Clinical Trial
An improved urine collection pad method: a randomised clinical trial.
To evaluate a modified urine collection pad (UCP) method for its ability to reduce heavy mixed growth bacterial contamination of UCP samples in young children with suspected urinary tract infection (UTI). ⋯ Changing the UCP every 30 minutes almost eliminates heavy mixed growth contamination of UCP samples and substantially increases the proportion of UCP results that confidently exclude UTI. This represents a simple and clinically important improvement to the UCP method which is reliable for diagnosing and excluding UTI in young children still in nappies. It has potential for use in outpatient clinics, in the primary healthcare setting, or at home.
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Randomized Controlled Trial Clinical Trial
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants.
To test the suitability of a simple once daily (OD) gentamicin regimen for use in young infants where routine therapeutic drug monitoring is not possible. ⋯ A "two, four, six, eight" OD gentamicin regime, appropriate for premature infants and those in the first days and weeks of life, seems a suitable, safe prescribing guide in resource poor settings.
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Randomized Controlled Trial Comparative Study Clinical Trial
Nebuliser hood compared to mask in wheezy infants: aerosol therapy without tears!
Small volume nebulisers (SVNs) with masks commonly provide aerosol therapy for infants with lung diseases. However, infants and toddlers are often disturbed by and thus reject masks. ⋯ Aerosol therapy by hood is as efficient as by mask but provides a better therapeutic index. It is much better tolerated by infants and preferred by parents. Hood nebulisation is a simple and patient friendly mode of aerosol therapy in wheezy infants.