Archives of disease in childhood
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Randomized Controlled Trial Clinical Trial
A comparison of local anaesthetics for venepuncture.
To compare the effectiveness of EMLA cream and Ametop gel in providing analgesia for venous cannulation. ⋯ Both anaesthetic agents produced adequate analgesia. However, Ametop gel was more effective, with a statistically significant difference in the pain scores of the two groups (p < 0.05).
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Randomized Controlled Trial Multicenter Study Clinical Trial
Randomised placebo controlled trial of nebulised corticosteroids in acute respiratory syncytial viral bronchiolitis.
To evaluate short and long term effects of giving nebulised budesonide early in respiratory syncytial viral (RSV) bronchiolitis. ⋯ There are no short or long term clinical benefits from the administration of nebulised corticosteroids in the acute phase of RSV bronchiolitis.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A randomised controlled trial to assess the relative benefits of large volume spacers and nebulisers to treat acute asthma in hospital.
To compare the clinical effectiveness, acceptability, and cost benefit of administering beta2 agonists by means of a metered dose inhaler and large volume spacer with conventional nebulisers to children admitted to hospital with acute asthma. ⋯ Large volume spacers are an acceptable, cost effective alternative to nebulisers in treating children admitted with acute asthma, provided that the children can use the mouthpiece, and symptoms are not severe. Their use facilitates effective home treatment by parents, with subsequent reduction in morbidity and re-admission rates.
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Randomized Controlled Trial Clinical Trial
Randomised controlled trial of aminophylline for severe acute asthma.
To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously. ⋯ Aminophylline continues to have a place in the management of severe acute asthma in children unresponsive to initial treatment.
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Randomized Controlled Trial Clinical Trial
Randomised controlled trial of sucrose by mouth for the relief of infant crying after immunisation.
To evaluate the effect of sucrose solution given by mouth on infant crying times and measures of distress in the immunisation clinic. ⋯ Infant immunisation by intramuscular injection is a distressing procedure for infants and parents. Sucrose solution at a high concentration reduces infant distress and is safe and clinically useful in this setting.