Health technology assessment : HTA
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Health Technol Assess · Dec 2014
ReviewOptical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation.
Age-related macular degeneration is the most common cause of sight impairment in the UK. In neovascular age-related macular degeneration (nAMD), vision worsens rapidly (over weeks) due to abnormal blood vessels developing that leak fluid and blood at the macula. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Nov 2014
ReviewThe clinical effectiveness and cost-effectiveness of second-eye cataract surgery: a systematic review and economic evaluation.
Elective cataract surgery is the most commonly performed surgical procedure in the NHS. In bilateral cataracts, the eye with greatest vision impairment from cataract is operated on first. First-eye surgery can improve vision and quality of life. However, it is unclear whether or not cataract surgery on the second eye provides enough incremental benefit to be considered clinically effective and cost-effective. ⋯ This project was funded by the National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Oct 2014
ReviewKRAS mutation testing of tumours in adults with metastatic colorectal cancer: a systematic review and cost-effectiveness analysis.
Bowel cancer is the third most common cancer in the UK. Most bowel cancers are initially treated with surgery, but around 17% spread to the liver. When this happens, sometimes the liver tumour can be treated surgically, or chemotherapy may be used to shrink the tumour to make surgery possible. Kirsten rat sarcoma viral oncogene (KRAS) mutations make some tumours less responsive to treatment with biological therapies such as cetuximab. There are a variety of tests available to detect these mutations. These vary in the specific mutations that they detect, the amount of mutation they detect, the amount of tumour cells needed, the time to give a result, the error rate and cost. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Oct 2014
ReviewThe clinical effectiveness and cost-effectiveness of peginterferon alfa and ribavirin for the treatment of chronic hepatitis C in children and young people: a systematic review and economic evaluation.
Optimal therapy for children with chronic hepatitis C is unclear. Two treatment regimens are currently licensed in children. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Sep 2014
ReviewA systematic review and economic evaluation of diagnostic strategies for Lynch syndrome.
Lynch syndrome (LS) is an inherited autosomal dominant disorder characterised by an increased risk of colorectal cancer (CRC) and other cancers, and caused by mutations in the deoxyribonucleic acid (DNA) mismatch repair genes. ⋯ The National Institute for Health Research Health Technology Assessment programme.