Health technology assessment : HTA
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Health Technol Assess · Mar 2014
ReviewPercutaneous vertebroplasty and percutaneous balloon kyphoplasty for the treatment of osteoporotic vertebral fractures: a systematic review and cost-effectiveness analysis.
Percutaneous vertebroplasty (PVP) is a minimally invasive surgical procedure in which bone cement is injected into a fractured vertebra. Percutaneous balloon kyphoplasty (BKP) is a variation of this approach, in which an inflatable balloon tamp is placed in the collapsed vertebra prior to cement injection. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Mar 2014
ReviewIvacaftor for the treatment of patients with cystic fibrosis and the G551D mutation: a systematic review and cost-effectiveness analysis.
Ivacaftor (Kalydeco(®), Vertex Pharmaceuticals) is the first of a new class of drugs that target the underlying protein defect in cystic fibrosis (CF). It is aimed at patients with the G551D (glycine to aspartate change in nucleotide 1784 in exon 11) mutation; 5.7% of patients with CF in the UK have this mutation. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Mar 2014
ReviewRoutine echocardiography in the management of stroke and transient ischaemic attack: a systematic review and economic evaluation.
Identification of the underlying cause of stroke and transient ischaemic attack (TIA) is important so that preventative therapy can be used to reduce the risk of recurrence. Transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE) are diagnostic tools used to identify those cardiac sources of stroke that may respond to treatment. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Feb 2014
ReviewEducational interventions for preventing vascular catheter bloodstream infections in critical care: evidence map, systematic review and economic evaluation.
Bloodstream infections resulting from intravascular catheters (catheter-BSI) in critical care increase patients' length of stay, morbidity and mortality, and the management of these infections and their complications has been estimated to cost the NHS annually £19.1-36.2M. Catheter-BSI are thought to be largely preventable using educational interventions, but guidance as to which types of intervention might be most clinically effective is lacking. ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Feb 2014
ReviewEnhancements to angioplasty for peripheral arterial occlusive disease: systematic review, cost-effectiveness assessment and expected value of information analysis.
There have been rapid technological developments aimed at improving short- and long-term results of percutaneous transluminal balloon angioplasty (PTA) in peripheral arterial occlusive disease (PAD). ⋯ The National Institute for Health Research Health Technology Assessment programme.