Health technology assessment : HTA
-
Health Technol Assess · Aug 2016
ReviewImmunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model.
End-stage renal disease is a long-term irreversible decline in kidney function requiring renal replacement therapy: kidney transplantation, haemodialysis or peritoneal dialysis. The preferred option is kidney transplantation, followed by immunosuppressive therapy (induction and maintenance therapy) to reduce the risk of kidney rejection and prolong graft survival. ⋯ The National Institute for Health Research Health Technology Assessment programme.
-
Health Technol Assess · Jul 2016
Multicenter Study Observational StudyThe Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.
It is not clear which young children presenting acutely unwell to primary care should be investigated for urinary tract infection (UTI) and whether or not dipstick testing should be used to inform antibiotic treatment. ⋯ The National Institute for Health Research Health Technology Assessment programme.
-
Health Technol Assess · Jul 2016
Randomized Controlled Trial Multicenter StudyPsychoeducation with problem-solving (PEPS) therapy for adults with personality disorder: a pragmatic randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of a manualised intervention to improve social functioning.
If effective, less intensive treatments for people with personality disorder have the potential to serve more people. ⋯ We aim to investigate adverse events by accessing centrally held NHS data on deaths and hospitalisation for all PEPS trial participants.
-
Health Technol Assess · Jul 2016
ReviewA cost-effectiveness modelling study of strategies to reduce risk of infection following primary hip replacement based on a systematic review.
A deep infection of the surgical site is reported in 0.7% of all cases of total hip arthroplasty (THA). This often leads to revision surgery that is invasive, painful and costly. A range of strategies is employed in NHS hospitals to reduce risk, yet no economic analysis has been undertaken to compare the value for money of competing prevention strategies. ⋯ The National Institute for Health Research Health Technology Assessment programme and the Queensland Health Quality Improvement and Enhancement Programme (grant number 2008001769).
-
Health Technol Assess · Jul 2016
Randomized Controlled TrialCan text messages increase safer sex behaviours in young people? Intervention development and pilot randomised controlled trial.
Younger people bear the heaviest burden of sexually transmitted infections (STIs). Partner notification, condom use and STI testing can reduce infection but many young people lack the knowledge, skills and confidence needed to carry out these behaviours. Text messages can provide effective behavioural support. The acceptability and feasibility of a randomised controlled trial of safer sex support delivered by text message are not known. ⋯ Our research shows that the intervention is acceptable and feasible to deliver. Our pilot trial demonstrated that a main trial is feasible. It remains unclear which behaviour change techniques and elements of the intervention or follow-up procedures are associated with effectiveness. A further limitation is that in the trial one person entering data and the participants were unmasked. A randomised controlled trial to establish the effects of the intervention on STIs at 12 months is needed.