The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
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Int. J. Tuberc. Lung Dis. · May 2011
Review Meta AnalysisInterleukin-10 polymorphisms and tuberculosis susceptibility: a meta-analysis.
A large number of studies have shown that polymorphisms in the interleukin 10 (IL-10) gene are implicated in susceptibility to tuberculosis (TB). However, the results are inconsistent and inconclusive. ⋯ This meta-analysis suggests that the -1082G/A polymorphism of the IL-10 gene could be a risk factor for TB in Europeans. Further studies with larger populations are required to assess the association between IL-10 polymorphisms and TB susceptibility.
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Int. J. Tuberc. Lung Dis. · Jan 2010
Review Meta AnalysisVitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis.
Host genetic susceptibility has been suggested as one of the most important explanations for inter-individual differences in tuberculosis (TB) risk. The vitamin D receptor (VDR) gene has been studied as a candidate locus due to genetic polymorphisms that affects the activity of the receptor and subsequent downstream vitamin D-mediated effects. ⋯ The association of VDR polymorphisms with risk of TB observed in our analyses supports the hypothesis that vitamin D deficiency might play a role as risk factor during the development of TB.