The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
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Int. J. Tuberc. Lung Dis. · Jul 2011
Randomized Controlled TrialEarly bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients.
Delamanid (OPC-67683) is a novel mycolic acid biosynthesis inhibitor active against Mycobacterium tuberculosis at a low minimum inhibitory concentration. ⋯ Delamanid at all dosages was safe, well tolerated and demonstrated significant exposure-dependent EBA over 14 days, supporting further investigation of its pharmacokinetics and anti-tuberculosis activity.
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Int. J. Tuberc. Lung Dis. · Jun 2011
Randomized Controlled TrialRisk of tuberculosis among contacts of isoniazid-resistant and isoniazid-susceptible cases.
To compare the risk to household contacts of isoniazid (INH) susceptible and INH-resistant cases of tuberculosis (TB) in a rural community in South India. ⋯ The baseline prevalence of tuberculous infection was substantially higher in contacts of INH-resistant than INH-susceptible patients, but the incidence of tuberculous disease over a 15-year follow-up was similar in the two series, and twice as high as in non-contacts.
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Int. J. Tuberc. Lung Dis. · Jun 2011
Randomized Controlled Trial Multicenter StudyResults at 30 months of a randomised trial of two 8-month regimens for the treatment of tuberculosis.
An 8-month isoniazid (INH, H) and ethambutol (EMB, E) based regimen recommended by the World Health Organization (WHO) had never been evaluated in a randomised controlled multicentre trial. ⋯ These results confirm earlier findings demonstrating the inferiority of the INH+EMB-based regimens to the standard 6-month regimen. The WHO has withdrawn its recommendation of these regimens.
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Int. J. Tuberc. Lung Dis. · May 2011
Review Meta AnalysisInterleukin-10 polymorphisms and tuberculosis susceptibility: a meta-analysis.
A large number of studies have shown that polymorphisms in the interleukin 10 (IL-10) gene are implicated in susceptibility to tuberculosis (TB). However, the results are inconsistent and inconclusive. ⋯ This meta-analysis suggests that the -1082G/A polymorphism of the IL-10 gene could be a risk factor for TB in Europeans. Further studies with larger populations are required to assess the association between IL-10 polymorphisms and TB susceptibility.
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Int. J. Tuberc. Lung Dis. · May 2011
The functioning of oxygen concentrators in resource-limited settings: a situation assessment in two countries.
The paediatric wards of hospitals in Malawi and Mongolia. ⋯ Years after installation of oxygen concentrators, many machines were still functioning, indicating that widespread use can be sustained in resource-limited settings. However, concentrator performance varied substantially. Procurement of high-quality and appropriate equipment is critical, and resources should be made available for ongoing maintenance.