CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
The most recent articles from:
CMAJ
-
Comparative Study
Risk of febrile seizures after first dose of measles-mumps-rubella-varicella vaccine: a population-based cohort study.
The combination measles-mumps-rubella-varicella (MMRV) vaccine currently used in Canada (Priorix-Tetra) may increase the risk of febrile seizures relative to the separate vaccines (MMR and varicella) previously administered. We determined the risk of febrile seizure after the first dose of MMRV, as well as any additional risk for children at high risk for seizures because of pre-existing medical conditions. ⋯ Despite an increased risk of febrile seizures following MMRV (compared with MMR+V), the absolute level of risk was small. Policy-makers need to balance these findings with the potential benefits of administering the combination vaccine or determine whether the choice of vaccine rests with clinicians and/or parents.