CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
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CMAJ
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Randomized Controlled Trial Multicenter Study
Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial.
The true benefit of iron supplementation for nonanemic menstruating women with fatigue is unknown. We studied the effect of oral iron therapy on fatigue and quality of life, as well as on hemoglobin, ferritin and soluble transferrin receptor levels, in nonanemic iron-deficient women with unexplained fatigue. ⋯ Iron supplementation should be considered for women with unexplained fatigue who have ferritin levels below 50 μg/L. We suggest assessing the efficiency using blood markers after six weeks of treatment. Trial registration no. EudraCT 2006-000478-56.