British journal of anaesthesia
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Comparative Study
Potency of atracurium and vecuronium at the diaphragm and the adductor pollicis muscle.
Train-of-four stimulation was applied to the ulnar and phrenic nerves in 18 adult patients anaesthetized with nitrous oxide and halothane in oxygen. The response of the adductor pollicis and the diaphragm were measured. Incremental doses of atracurium and vecuronium were given, with an infusion to replace drug lost by elimination or distribution. ⋯ The mean (SEM) ED50 ratios were 1.56 (0.16) for atracurium and 1.47 (0.16) for vecuronium. ED90 ratios were 1.93 (0.29) and 1.55 (0.17) for atracurium and vecuronium, respectively. It is concluded that both atracurium and vecuronium exhibit a similar degree of sparing of the diaphragm.
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Ten obstetric patients received 17-20 ml of autologous blood through an extradural catheter after inadvertent dural puncture. The time interval from dural puncture to prophylactic extradural blood patch ranged from 90 to 660 min. One of the 10 patients developed a mild occipital headache, which required no further intervention.
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Letter Case Reports
Use of naloxone in opioid-induced anaphylactoid reaction.