British journal of anaesthesia
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Randomized Controlled Trial Comparative Study
Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia.
Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT(3)) receptor. As 5-HT(3) receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. ⋯ Despite knowing the 5-HT(3) antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.
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Randomized Controlled Trial
Withdrawal forces of lumbar spinal catheters: no dependence on body position.
Spinal catheters, because of their smaller diameter, have lower tensile strength than epidural catheters. This study was designed to measure the withdrawal forces needed to remove lumbar spinal catheters and to determine whether patient position affects withdrawal forces. ⋯ Withdrawal force of spinal catheters is not influenced by body position during catheter removal, length of catheter under skin, or BMI.
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Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients.
Blood loss and uncontrollable bleeding are major factors affecting survival in trauma patients. Because treatment with antifibrinolytic drugs may be effective, early detection of hyperfibrinolysis with rotation thrombelastography (ROTEM may be beneficial. ⋯ ROTEM provided rapid and accurate detection of hyperfibrinolysis in severely injured trauma patients.
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Letter Randomized Controlled Trial
Does celecoxib have pre-emptive analgesic effect after Caesarean section surgery?
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Respiratory depression limits the use of opioid analgesia. Although well described clinically, the specific mechanisms of opioid action on respiratory control centres in the brain have, until recently, been less well understood. ⋯ The ultimate aim of combating opioid-induced respiratory depression would benefit patients in pain and potentially reduce deaths from opioid overdose. By integrating recent findings from animal studies with those from human volunteer and clinical studies, further avenues for investigation are proposed, which may eventually lead to safer opioid analgesia.