British journal of anaesthesia
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The aim of this study was to assess any interaction between ondansetron and paracetamol on a model of post-fracture pain in mice. ⋯ We found that paracetamol 100 mg kg⁻¹ blocked the development of hyperalgesia and allodynia after fracture pain and ondansetron did not modify the antinociceptive effect of paracetamol in this model.