British journal of anaesthesia
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Letter Multicenter Study
Goal-directed therapy: each therapeutic regimen needs its indication.
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Carbamazepine and pregabalin have proven effects against neuropathic pain. Carbamazepine blocks voltage-dependent Na(+) channels, whereas pregabalin blocks voltage-dependent Ca(2+) channels. The authors hypothesized that the co-administration of these drugs would synergistically reduce neuropathic pain. ⋯ Carbamazepine and pregabalin ameliorate neuropathic pain synergistically at higher doses.