British journal of anaesthesia
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There is limited understanding of cortical neurochemistry and cortical connectivity during ketamine anaesthesia. We conducted a systematic study to investigate the effects of ketamine on cortical acetylcholine (ACh) and electroencephalographic coherence. ⋯ Ketamine-induced unconsciousness is characterized by suppression of high-frequency gamma activity and a breakdown of cortical coherence, despite increased cholinergic tone in the cortex.
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Letter Randomized Controlled Trial Comparative Study
Structured approach to ultrasound-guided identification of the cricothyroid membrane: a randomized comparison with the palpation method in the morbidly obese.
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In the original article, under the "Declaration of Interests" section, the authors stated "none declared" since they had no direct interest in the use of local anaesthetics to treat cancer (the focus of the article being the beneficial use of local anaesthetics in cancer surgery). However, they do have a pending patent on blockers that specifically target the persistent current component of voltage-gated sodium channels, as anti-metastatic agents.
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Editorial Comment
'Paradox' of troponin elevations after non-cardiac surgery.