British journal of anaesthesia
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Review Meta Analysis
Effect of beta-blockers on perioperative outcomes in vascular and endovascular surgery: a systematic review and meta-analysis.
To investigate the role of perioperative beta-blocker use in vascular and endovascular surgery. ⋯ Beta-blockers do not improve perioperative outcomes in vascular and endovascular surgery.
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This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.