British journal of anaesthesia
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Randomized Controlled Trial
Randomised controlled trial comparing preoperative carbohydrate loading with standard fasting in paediatric anaesthesia.
Preoperative fasting is a major cause of perioperative discomfort in paediatric anaesthesia and leads to postoperative insulin resistance, thus potentially enhancing the inflammatory response to surgery. Addressing these problems by preoperative carbohydrate intake has not been a well-defined approach in children. ⋯ DRKS00005020.
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Multicenter Study
Conditioned pain modulation identifies altered sensitivity in extremely preterm young adult males and females.
Conditioned pain modulation is a potential biomarker for risk of persistent pain. As early-life experience can alter subsequent somatosensory processing and pain response, we evaluated conditioned pain modulation after extremely preterm birth. ⋯ Cold conditioning evoked inhibitory modulation in the majority of young adults and identified a subgroup of extremely preterm females with increased baseline sensitivity. Early-life experience and sex/gender should be considered when evaluating persistent pain risk with conditioned pain modulation.
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Randomized Controlled Trial Comparative Study
Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults.
The choice of general anaesthetics may affect postoperative cognitive outcomes. This study was designed to compare the potential impact of propofol-based vs sevoflurane-based general anaesthesia on the development of delayed neurocognitive recovery in older adults early after major cancer surgery. ⋯ NCT02662257; Chinese Clinical Trial Registry (identifier: ChiCTR-IPR-15006209).
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Clinical Trial
Population pharmacokinetic analysis of propofol in underweight patients under general anaesthesia.
The modified Marsh and Schnider pharmacokinetic models for propofol consistently produce negatively and positively biased predictions in underweight patients, respectively. We aimed to develop a new pharmacokinetic model of propofol in underweight patients. ⋯ KCT0001760.