British journal of anaesthesia
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Nerve growth factor (NGF) has been implicated in hyperalgesia by sensitising nociceptors. A role for NGF in modulating myocardial injury through ischaemic nociceptive signalling is plausible. We examined whether inhibition of spinal NGF attenuates myocardial ischaemia-reperfusion injury and explored the underlying mechanisms. ⋯ Spinal NGF contributes to myocardial ischaemia-reperfusion injury by mediating nociceptive signal transmission.
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Editorial Comment
Machine learning in anaesthesia: reactive, proactive… predictive!