British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Differential modulation of interleukin-6 and interleukin-10 by diclofenac in patients undergoing major surgery.
Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin (IL) 6 and IL-10. Diclofenac inhibits cyclo-oxygenase activity and hence prostaglandin production. We hypothesized that diclofenac would affect release of IL-6 and IL-10 and modulate the immune response. ⋯ Administration of diclofenac was associated with lower IL-6 and higher IL-10 concentrations, and lower leucocyte count, C-reactive protein concentration and temperature. Diclofenac may have an anti-inflammatory role in major surgery.
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Randomized Controlled Trial Clinical Trial
Pre-emptive effect of epidural sufentanil in abdominal hysterectomy.
Experimental studies suggest pre-emptive administration of analgesics is effective but clinical evidence is less convincing. ⋯ We conclude that pre-emptive analgesia with epidural sufentanil was associated with a short-term sufentanil-sparing effect, and could have reduced stress hormone responses and wound sensitization after abdominal hysterectomy.
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Randomized Controlled Trial Clinical Trial
Comparison of caudal and intravenous clonidine in the prevention of agitation after sevoflurane in children.
In children, sevoflurane anaesthesia is associated with postanaesthetic agitation, which is treated mainly with opioids. We compared the effectiveness of epidural and i.v. clonidine in the prevention of this postanaesthetic agitation. ⋯ Clonidine 3 micrograms kg-1 prevented agitation after sevoflurane anaesthesia, independently of the route of administration. The effect of clonidine appears to be dose-dependent, as an epidural dose of 1 microgram kg-1 failed to reduce it.
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Randomized Controlled Trial Clinical Trial
ProSeal versus the Classic laryngeal mask airway for positive pressure ventilation during laparoscopic cholecystectomy.
We tested the hypothesis that the ProSeal laryngeal mask airway (PLMA) is a more effective ventilatory device than the Classic laryngeal mask airway (LMA) for laparoscopic cholecystectomy. ⋯ The PLMA is a more effective ventilatory device for laparoscopic cholecystectomy than the LMA. We do not recommend the use of the LMA for laparoscopic cholecystectomy.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of the effects of sevoflurane and propofol on cortical somatosensory evoked potentials.
Propofol (P) and sevoflurane (S) are potential anaesthetic agents if electrophysiological monitoring is required during spinal surgery. They allow rapid recovery and do not depress cortical somatosensory evoked potentials (SSEP) as much as other agents. The effects of these agents on SSEP have not been compared before. ⋯ Sevoflurane affected SSEP recordings in a dose-dependent fashion. Propofol had a minimal effect on SSEP recordings.