British journal of anaesthesia
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Diaspirin cross-linked haemoglobin (DCLHb) is a new oxygen carrying blood substitute with vasoactive properties. Vasoactive properties may be mediated via high affinity binding of nitric oxide by the haem moiety. Using a rodent model of head injury combined with ischaemia, we studied the effects of DCLHb on cerebral blood flow (CBF) and intracranial pressure (ICP). ⋯ Mean arterial pressure (MAP), ICP, cerebral perfusion pressure (CPP) (CPP = MAP - ICP) and CBF were measured 4 h after injury in all animals. DCLHb significantly reduced ICP from mean 13 (SEM 2) to 3 (1) mm Hg (P < 0.001), increased CPP from 52 (8) to 95 (6) mm Hg (P < 0.001) and increased CBF from 21 (2) to 29 (2) ml 100 g-1 min-1 (P = 0.032). We conclude that DCLHb improved CPP without a reduction in CBF in a rodent model of post-traumatic brain swelling.
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We studied six operating department assistants performing simulated cricoid pressure on a model of the larynx with the arm either flexed to 90 degrees (flexed position) or fully extended with the elbow locked (extended position). Subjects were asked to maintain forces of 20, 30 and 40 Newtons (N) for a target time of 20 min. Subjects rated pain during each assessment on a four-point verbal rating scale (VRS): 1 = uncomfortable; 2 = hurting; 3 = hurting a lot; and 4 = agony. ⋯ Mean times to release at 20 N were: flexed position (four subjects) 13.2 min, extended position (one subject) 14.6 min. Use of the extended arm consistently prolonged times to pain and fatigue. These findings are relevant to the management of cricoid pressure during failed intubation.
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Biography Historical Article Classical Article
Anaesthesia for caesarean section. 1970.
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Randomized Controlled Trial Comparative Study Clinical Trial
Induction and emergence in infants less than 60 weeks post-conceptual age: comparison of thiopental, halothane, sevoflurane and desflurane.
We have studied 40 infants with a post-conceptual age of less than 60 weeks undergoing general anaesthesia for herniotomy. Patients were anaesthetized with 1 MAC equivalent values for age and agent and allocated randomly to receive halothane, savoflurane or thiopental for induction, and halothane, sevoflurane or desflurane for maintenance of anaesthesia. At induction, both time to acceptance of a face mask and loss of eyelash reflex were recorded. ⋯ Induction of anaesthesia in this population was no quicker with sevoflurane than with halothane and the method used for induction did not influence recovery time. Maintenance of anaesthesia with desflurane resulted in a shorter recovery time in infants in whom anaesthesia was induced with halothane or thiopental. Desflurane maintenance may be particularly beneficial in the neonate.