British journal of anaesthesia
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Randomized Controlled Trial
Intrathecal morphine does not prevent chronic postsurgical pain after elective Caesarean delivery: a randomised controlled trial.
Morphine is frequently added to spinal anaesthesia for Caesarean delivery. We aimed to determine whether intrathecal morphine for spinal anaesthesia decreases the risk of chronic postsurgical pain (CPSP). ⋯ NCT03451695.
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Multicenter Study Observational Study
Preoperative anaemia and outcome after elective cardiac surgery: a Dutch national registry analysis.
Previous studies have shown that preoperative anaemia in patients undergoing cardiac surgery is associated with adverse outcomes. However, most of these studies were retrospective, had a relatively small sample size, and were from a single centre. The aim of this study was to analyse the relationship between the severity of preoperative anaemia and short- and long-term mortality and morbidity in a large multicentre national cohort of patients undergoing cardiac surgery. ⋯ Preoperative anaemia was associated with mortality and morbidity after cardiac surgery. The risk of adverse outcomes increased with anaemia severity. Preoperative anaemia is a potential target for treatment to improve postoperative outcomes.
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The impact of opioid analgesic use before cancer diagnosis on survival in patients with chronic pain is unclear. Therefore, we designed a propensity score-matched population-based cohort study to compare overall and cancer-related survival of patients with chronic pain who received long-term opioid analgesic treatment with that of those who did not receive such treatment. ⋯ Long-term opioid analgesic use before cancer diagnosis might be associated with poor overall survival in patients with chronic pain compared with such patients who did not receive long-term opioid analgesics.
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Letter Meta Analysis
Metformin and mortality after surgery: a systematic review and meta-analysis.
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Editorial Comment
Preoperative anaemia in cardiac surgery: preoperative assessment, treatment and outcome.
Preoperative anaemia is common and associated with increased postoperative morbidity and mortality after cardiac surgery. These findings are supported by a large Dutch cohort study including >35 000 patients published in this issue of the British Journal of Anaesthesia. Timely diagnosis and preoperative anaemia treatment seem to be reasonable targets for perioperative risk stratification and modification. However, implementation of anaemia therapy into clinical routines remains challenging, and evidence for improved outcome is currently limited.