British journal of anaesthesia
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Comparative Study
Dimensional compatibility of currently available equipment for cricothyroidotomy and adult airway anatomy: an in vitro analysis.
There are scant data on the dimensional compatibility of cricothyroidotomy equipment and related airway anatomy. We compared the dimensional design of devices for cricothyroidotomy with anatomical airway data for adult patients. ⋯ The outer diameter of many devices currently marketed for cricothyroidotomy are oversized for adult airway anatomy, particularly for females. For emergency front-of-neck access through the cricothyroid membrane, anatomical data suggest that cricothyroidotomy devices with outer tube diameters of <7 mm for male and <6 mm for female adult patients should be preferred.
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It is unclear whether the innate immune response represents a therapeutic target for organ protection strategies in cardiac surgery. ⋯ The certainty of the evidence for a causal relationship between innate immune system activation and organ injury after cardiac surgery is low.
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Review Meta Analysis
Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis.
Postoperative delirium has eluded attempts to define its complex aetiology and describe specific risk factors. The role of neuroinflammation as a risk factor, determined by measuring blood levels of preoperative 'innate' inflammatory mediator levels, has been investigated. However, results have been conflicting. We conducted a systematic review and meta-analysis of the evidence on associations between preoperative blood levels of inflammatory mediators and postoperative delirium in the older person. Influence of type of surgery was also assessed. ⋯ CRD42019159471 (PROSPERO).