British journal of anaesthesia
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Multicenter Study
Associations between perioperative fluid management and patient outcomes: a multicentre retrospective study.
Postoperative complications increase hospital length of stay and patient mortality. Optimal perioperative fluid management should decrease patient complications. This study examined associations between fluid volume and noncardiac surgery patient outcomes within a large multicentre US surgical cohort. ⋯ Both very high and very low perioperative fluid volumes were associated with an increase in complications after noncardiac surgery.
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Randomized Controlled Trial Multicenter Study
Multicentre randomised controlled clinical trial of electroacupuncture with usual care for patients with non-acute pain after back surgery.
The purpose of this study was to investigate the effectiveness and safety between electroacupuncture (EA) combined with usual care (UC) and UC alone for pain reduction and functional improvement in patients with non-acute low back pain (LBP) after back surgery. ⋯ KCT0001939.
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Nerve injury-induced changes in gene expression in the dorsal root ganglion (DRG) contribute to neuropathic pain genesis. Eukaryotic initiation factor 4 gamma 2 (eIF4G2) is a general repressor of cap-dependent mRNA translation. Whether DRG eIF4G2 participates in nerve injury-induced alternations in gene expression and nociceptive hypersensitivity is unknown. ⋯ eIF4G2 contributes to neuropathic pain through participation in downregulation of Kv1.2 and MOR in injured DRG and is a potential target for treatment of this disorder.