British journal of anaesthesia
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Review Comparative Study
Comparison of anaesthetic- and seizure-induced states of unconsciousness.
In order to understand general anaesthesia and certain seizures, a fundamental understanding of the neurobiology of unconsciousness is needed. This review article explores similarities in neuronal and network changes during general anaesthesia and seizure-induced unconsciousness. ⋯ These areas are all likely to be involved in maintaining normal consciousness. An assessment of the similarities in the brain network disruptions with certain seizures and general anaesthesia might provide fresh insights into the mechanisms of the alterations of consciousness seen in these particular unconscious states, allowing for innovative therapies for seizures and the development of anaesthetic approaches targeting specific networks.
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Review Meta Analysis
Pharmacological interventions for the prevention of renal injury in surgical patients: a systematic literature review and meta-analysis.
The aim of this systematic review was to summarise the results of randomised controlled trials (RCTs) that have evaluated pharmacological interventions for renoprotection in people undergoing surgery. ⋯ There are multiple effective pharmacological renoprotective interventions for people undergoing surgery.
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Multicenter Study
Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial.
Intravenous tranexamic acid (TXA) reduces bleeding deaths after injury and childbirth. It is most effective when given early. In many countries, pre-hospital care is provided by people who cannot give i.v. injections. We examined the pharmacokinetics of intramuscular TXA in bleeding trauma patients. ⋯ 2019-000898-23 (EudraCT); NCT03875937 (ClinicalTrials.gov).