British journal of anaesthesia
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Review Meta Analysis
Intravenous lidocaine to prevent postoperative airway complications in adults: a systematic review and meta-analysis.
Cough: why care?
Although often minor, common post-operative complications have by definition a broad impact on the perioperative experience. Some common complications, such as coughing on extubation, can also have significant surgical consequences such as for neurosurgical or ophthalmic procedures.
Both coughing on extubation (reported incidence 15-94%) and post-operative sore throat (21-72%) are very common among surgical patients.
What did they do?
Yang and team performed a high-quality meta-analysis of RCTs investigating the effect of intravenous lidocaine/lignocaine on coughing at extubation. Many of these trials also looked at further secondary effects, such as post-operative sore throat. They included 16 trials, totalling 1,516 subjects. Although the trials demonstrated significant heterogeneity, subgroup analyses still confirmed the study's findings.
And they found...
There was significant reduction in cough RR 0.64 (0.48-0.86 & NNT=5), and post-operative sore throat RR 0.46 (0.32-0.67), though no difference in laryngospasm, adverse events or time to extubation with modern volatile agents.
Analysing various lidocaine timings (pre-operative vs intra-operative) and dose ranges (low <1.5mg/kg or high >1.5 mg/kg) yielded no evidence of clear advantage. Nonetheless the findings are consistent with previous reviews, such as from Clivio et al. (2019) showing lidocaine 1.5 mg/kg reduced cough (RR: 0.44; 0.33–0.58), and that the effect is probably dose responsive.
Ok, but how does lidocaine work?
The mechanism of action reducing cough is not understood, although several possibilities have been proposed, including...
"...the suppression of airway sensory C fibres, the reduction of neural discharge of peripheral nerve fibres, and the selective depression of pain transmission in the spinal cord."
Bottom-line
Peri-operative intravenous lignocaine effectively reduces coughing on extubation and reduces post-operative sore throat, without any increase in adverse events.
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Review
Immune checkpoint inhibitors: a narrative review of considerations for the anaesthesiologist.
Immunotherapy has revolutionised the treatment of oncologic malignancies. Immune checkpoint inhibitors represent a new class of immunotherapy drugs. ⋯ An increasing number of patients who undergo surgery will have had treatment with immune checkpoint inhibitors. In this narrative review article, we discuss their mechanism of action, therapeutic effects, pertinent toxicities, and address specific perioperative considerations for patients treated with immune checkpoint inhibitors.
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A systematic literature search was performed to identify studies that reported risk factors for persistent pain after childbirth. Many studies have sought to identify risk factors for post-delivery pain in different populations, using different methodologies and different outcome variables. Studies of several different but interrelated post-partum pain syndromes have been conducted. ⋯ Unfortunately, limitations, particularly small samples and lack of a priori sample size calculation designed to detect specific effect sizes for risk of persistent pain outcomes, preclude definitive conclusions about many other predictors and the strength of outcome associations. In future studies, assessments of specific phenotypes using a rigorous analysis with appropriate predetermined sample sizes and validated instruments are needed to allow elucidation of stronger and reliable associations. Interventional studies targeting the most robustly associated, modifiable risk factors, such as acute post-partum pain, may lead to solutions for the prevention and treatment of these common problems that impact a large population.
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Modern healthcare is delivered by interprofessional teams, and good leadership of these teams is integral to safe patient care. Good leadership in the operating theatre has traditionally been considered as authoritative, confident and directive, and stereotypically associated with men. We argue that this may not be the best model for team-based patient care and promote the concept of inclusive leadership as a valid alternative. ⋯ In this article we provide evidence on the advantages of inclusive leadership over authoritative leadership and explore gender stereotypes and obstacles that limit the recognition of inclusive leadership. We propose that operating teams rise above gender stereotypes of leadership. Inclusive leadership can elicit maximum performance of every team member, thus realising the full potential of interprofessional healthcare teams to provide the best care for patients.
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Women face gender-based challenges in their medical education and career. Inequitable access to procedural training, a confidence gap, and professional identity deficit have been shown. We made a gender comparison of procedural case volume, confidence for independent practice, perceived gender and ethnic bias, and professional identity in Australasian anaesthesia trainees. ⋯ A discrepancy exists between the number of procedures performed by male and female anaesthesia trainees in Australia and New Zealand. Relative male overconfidence may be a major contributing factor to the gender confidence gap.