British journal of anaesthesia
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Randomized Controlled Trial
Lung protective ventilation during pulmonary resection in children: a prospective, single-centre, randomised controlled trial.
Perioperative ventilatory strategies for lung protection in children are underexplored. This study evaluated the effects of lung protective ventilation (LPV) on postoperative clinical outcomes in children requiring one-lung ventilation (OLV) for pulmonary resection. ⋯ NCT02680925.
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Individuals genetically susceptible to malignant hyperthermia (MH) exhibit hypermetabolic reactions when exposed to volatile anaesthetics. Mitochondrial dysfunction has previously been associated with the MH-susceptible (MHS) phenotype in animal models, but evidence of this in human MH is limited. ⋯ We present evidence of mitochondrial dysfunction in human MHS skeletal muscle both at baseline and after halothane exposure.
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This review offers a perspective on the future of paediatric sedation. This future will require continued evaluation of adverse events, their risk factors, and predictors. ⋯ Understanding the mechanism and location of action of the different sedatives will remain an important focus. Important developments in paediatric sedation will require that large scale studies with global data contribution be conducted in order to support changes in sedation practice, improve the patient experience, and make sedation safer.
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Editorial Comparative Study
Critical airway management in the intensive care unit: homogeneity in practice?