International journal of clinical practice
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Int. J. Clin. Pract. · Dec 2020
Randomized Controlled TrialA Comparative Study for the Effects of Nifedipine GITS and Amlodipine Besylate Administrated in Daytime or at Nighttime on Recovery of Blood Pressure Rhythm and Arterial Stiffness in the Young and Middle-aged Subjects with Non-dipper Hypertension (NARRAS): Design and Rationale.
Hypertensive patients with a blunted or absent nocturnal blood pressure (BP) drop (non-dipper) are associated with arterial stiffening and additional cardiovascular risk. Non-dipper hypertension is prevalent in young and middle-aged adults; but the optimal antihypertensive strategy remains unclear. There is a need to explore the effects of different antihypertensive agents and time of administration on recovery of dipper rhythm and arterial stiffness in this population. ⋯ NARRAS study is the first RCT to evaluate the effects of nifedipine GITS and amlodipine besylate on restoration of dipping rhythm and arterial elasticity, either administrated in the morning or evening, in younger non-dipper hypertensive subjects. The findings of NARRAS are likely to be potential to facilitate new therapeutic strategies for this condition.
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Int. J. Clin. Pract. · Dec 2020
Randomized Controlled TrialComparing the different oxycodone doses of prevent oxycodone for prevention of preventing fentanyl-induced cough during induction of general anesthesia.
Fentanyl-induced cough (FIC) usually occurs after the intravenous administration of fentanyl during general anaesthesia induction. It is a transient condition depending on the fentanyl administration dose and injection speed. Oxycodone can also prevent FIC because it has been proven to treat coughing. This study aimed to evaluate the efficacy of different oxycodone doses to prevent FIC during general anaesthesia induction. ⋯ Oxycodone 0.075 mg/kg provided more effective FIC prevention during general anaesthesia induction.
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Int. J. Clin. Pract. · Dec 2020
Randomized Controlled Trial Multicenter StudyEffect of Electroacupuncture in Pre- and Postmenopausal Women with Stress Urinary Incontinence.
To evaluate the effect of electroacupuncture and assess the impact of menopausal status in women with stress urinary incontinence or stress-predominant mixed urinary incontinence. ⋯ This subgroup analysis indicated that electroacupuncture can improve the symptoms of urinary incontinence in women with stress urinary incontinence or stress-predominant mixed urinary incontinence and that menopausal status may not affect the effects of electroacupuncture in subjects.
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Int. J. Clin. Pract. · Nov 2020
Randomized Controlled Trial Comparative StudyFebuxostat therapy in outpatients with suspected COVID-19: A clinical trial.
The aim of this clinical trial was to evaluate the effects of febuxostat (FBX) in comparison with hydroxychloroquine (HCQ) on clinical symptoms, laboratory tests and chest CT findings in outpatients with moderate symptoms of COVID-19 infection. ⋯ This trial suggests that FBX is as an alternative treatment to HCQ for COVID-19 infection and may be considered in patients with a contraindication or precaution to HCQ.
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Int. J. Clin. Pract. · Sep 2020
Randomized Controlled TrialOnabotulinumtoxin Type A reconstitution with preserved versus preservative-free saline in chronic migraine (B-RECON). A randomized, double-blind trial.
Onabotulinumtoxin type A (BoNTA) is manufactured as powder that requires reconstitution with normal saline prior to injection. Previous literature has suggested that preserved saline (PS) exerts a local anaesthetic effect, and reduces the procedure discomfort when used in reconstitution in lieu of preservative-free saline (PFS). However, this was mainly studied in the aesthetics indications of BoNTA, and never in its use for the treatment of chronic migraine. The distinction is important as chronic migraine population suffers high incidence of scalp allodynia which makes it more prone to injection site pain. In addition, the pain of the procedure itself may be related to the spike of migraine frequency in the immediate postprocedural period which can occur in up to 5% of patients receiving the treatment. Our trial aimed to study the difference in procedural pain scale, and postprocedural headache rating with the use of PS vs PFS in constitution of BoNTA when used as a treatment for chronic migraine. ⋯ This study supports the use of PS (bacteriostatic) over PFS for reconstitution of BoNTA in chronic migraine as it reduces the discomfort of the injection sites.