International journal of clinical practice
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Int. J. Clin. Pract. · Jul 2016
Randomized Controlled Trial Multicenter StudyTelemonitoring in heart failure patients treated by cardiac resynchronisation therapy with defibrillator (CRT-D): the TELECART Study.
Telemonitoring (TM) is a safe and efficient monitoring system for internal cardioverter defibrillator device (ICD) recipients. TM has been used to track info on the clinical status of heart failure patients treated by ICD and/or cardiac resynchronisation therapy defibrillator (CRT-D). The aim of this study was to investigate the impact of TM on clinical outcomes in a population of CRT-D patients with heart failure. ⋯ Taken together, our data indicate the importance of TM in predicting heart failure hospitalisation in patients treated with CRT-D.
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Int. J. Clin. Pract. · Jun 2016
Randomized Controlled TrialEfficacy and safety of fulranumab as monotherapy in patients with moderate to severe, chronic knee pain of primary osteoarthritis: a randomised, placebo- and active-controlled trial.
The efficacy and safety of monotherapy with fulranumab, a monoclonal antibody that neutralises human nerve growth factor (NGF), was evaluated compared with placebo and an active comparator, controlled-release (CR) oxycodone, in patients with moderate to severe chronic knee pain of primary osteoarthritis (OA). ⋯ Low sample size because of early termination make interpretation of this study difficult, but fulranumab monotherapy resulted in significantly better pain relief and function compared with oxycodone CR (but not against placebo) and was generally well-tolerated.
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Int. J. Clin. Pract. · Feb 2016
Randomized Controlled TrialA randomised, double-blinded study comparing giving etoricoxib vs. placebo to female patients with fibromyalgia.
Current therapeutic approaches to fibromyalgia syndrome (FMS) do not provide satisfactory pain control to a high percentage of patients. This unmet need constantly fuels the pursuit for new modalities for pain relief. This randomised, double-blind, controlled study assessed the efficacy and safety of adding etoricoxib vs. placebo to the current therapeutic regimen of female patients with FMS. ⋯ This is the first randomised, double-blind study assessing the effect of adding etoricoxib to pre-existing medications for female patients with FMS. Although being mildly underpowered this study clearly has shown that etoricoxib did not improve pain scores and did not lead to any beneficial mental or physical effects.
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Int. J. Clin. Pract. · Nov 2015
Randomized Controlled Trial Multicenter StudyInterventions do not enhance medication persistence and compliance in patients with overactive bladder: a 24 weeks, randomised, open-label, multi-center trial.
Anticholinergics are currently the mainstay for the management of overactive bladder (OAB). However, low drug adherence has been noted with these medications. The aim of this study was to determine whether a health education intervention (HEI) could improve drug persistence with anticholinergics in OAB patients. ⋯ The health education intervention was not effective to increase drug persistence in OAB patients on anticholinergics.
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Int. J. Clin. Pract. · Oct 2015
Randomized Controlled TrialAn investigation and comparison of the effectiveness of different exercise programmes in improving glucose metabolism and pancreatic β cell function of type 2 diabetes patients.
Moderately intensive aerobic exercise can improve glucose metabolism and pancreatic β cell function in diabetic patients. To date, there is no evidence to support the long-term effectiveness of home-based exercise interventions on these outcomes. ⋯ This study demonstrates that regardless of the type of exercise intervention, it is potentially beneficially effective for glucose metabolism and pancreatic β cell function in T2DM patients. The AMSG had better glucose metabolism and pancreatic β cell function compared with those in the AEG. Nurses can easily integrate exercise interventions into T2DM patient care plans.