International journal of clinical practice
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Int. J. Clin. Pract. · Apr 2008
Randomized Controlled Trial Multicenter Study Comparative StudyLipid-altering efficacy of ezetimibe/simvastatin 10/40 mg compared with doubling the statin dose in patients admitted to the hospital for a recent coronary event: the INFORCE study.
The aim of this study was to investigate the efficacy and safety profile of switching to ezetimibe/simvastatin (Eze/Simva) 10/40 mg compared with doubling the statin dose upon discharge in patients taking a statin and admitted to the hospital for the investigation of a coronary event. ⋯ In patients taking a statin and admitted to the hospital for investigation of a coronary event, treatment with Eze/Simva 10/40 mg for 12 weeks produced greater improvements in lipids with a similar safety profile compared with doubling of the statin dose.
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Int. J. Clin. Pract. · Feb 2008
Randomized Controlled TrialCombined spinal-epidural analgesia vs. intermittent bolus epidural analgesia for pain relief after major abdominal surgery. A prospective, randomised, double-blind clinical trial.
The primary aim of this study was to compare the efficacy of combined spinal-epidural (CSE) analgesia vs. intermittent bolus epidural analgesia (EA) for pain relief after major abdominal surgery. The secondary aim was to assess the effects of fentanyl addition to subarachnoid morphine and bupivacaine. ⋯ Combined spinal-epidural improved intra-operative analgesia and reduced pain with cough in the immediate postoperative period. The addition of fentanyl to subarachnoid morphine and bupivacaine decreased the need for additional i.v. fentanyl and epidural bupivacaine analgesia.
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Int. J. Clin. Pract. · Feb 2008
Randomized Controlled TrialThe efficacy of oxycodone for management of acute pain episodes in chronic neck pain patients.
Most treatments of acute pain associated with non-malignant chronic pains are not satisfactory. The aim of this study is to evaluate the efficacy and side effects of oxycondone controlled release (Oxy-CR) in managing chronic neck pain with acute pain episodes. ⋯ Oxycondone controlled release could be an important optional drug for the management of refractory and frequent acute episodes of chronic neck pain in patients who failed to respond to non-opioid conservative treatment.
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Int. J. Clin. Pract. · Feb 2008
Randomized Controlled Trial Comparative StudyEffect of levosimendan on right ventricular systolic and diastolic functions in patients with ischaemic heart failure.
Levosimendan is a novel positive inotropic calcium sensitiser agent used in acute left heart failure. In this study, the effect of levosimendan on the right ventricular systolic and diastolic functions was evaluated by tissue Doppler comparing them with dobutamine in patients with ischaemic heart failure. ⋯ Levosimendan improves right ventricular systolic and diastolic functions.
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Int. J. Clin. Pract. · Jan 2008
Randomized Controlled Trial Multicenter StudyEffects of oxybutynin transdermal system on health-related quality of life and safety in men with overactive bladder and prostate conditions.
Overactive bladder (OAB) is common in men and may exist concomitantly with benign prostatic hyperplasia (BPH) and obstruction. We present a subanalysis of results from men with OAB in a 6-month, open-label study of treatment with the oxybutynin transdermal system (OXY-TDS). Broad entry criteria were incorporated to yield a clinically representative population. ⋯ Oxybutynin transdermal system treatment of men with OAB was effective and well tolerated, regardless of history of prostate condition.